Cat. No.
MABL-2660
Application
IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
366C.9E5
From
Recombinant Antibody
Specificity
This antibody is specific for human PD-L2, and recognises an epitope in the IgV domain.
Alternative Names
CD273; Programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; PDCD1LG2; B7DC; PDCD1L2; PD L2; 9E5
UniProt
Q9BQ51
Immunogen
This antibody was raised by immunising mice with a recombinant protein fragment corresponding to the extracellular domain of human PD-L2 (as an Ig fusion protein).
Application Notes
This antibody has been used in the immunohistochemical detection of PD-L2 in formalin-fixed, paraffin-embedded tissue sections of Hodgkin's lymphoma tissue sections (Ansell et al, 2018; Roemer et al, 2016), primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma biopsies (Shi et al, 2014; Chong et al, 2016), non–small-cell lung cancer tumour samples (Calles et al, 2015), primary and metastatic adenoid cystic carcinoma deposits (Sridharan et al, 2016), and tonsil and colorectal carcinoma tissue samples (Masugi et al, 2017).
Antibody First Published
Shi et al. Expression of Programmed Cell Death 1 Ligand 2 (PD-L2) is a Distinguishing Feature of Primary Mediastinal (Thymic) Large B-cell Lymphoma and Associated with PDCD1LG2 Copy Gain Am J Surg Pathol. 2014 Dec; 38(12): 1715–1723. PMID:25025450
Note on publication
The article describes the original use of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
