Cat. No.
MABL-2681
Application
RIA, ELISA
Isotype
Engineer antibody
Species Reactivity
Species independent
Clone No.
mAbPGE
From
Recombinant Antibody
Specificity
Alternative Names
Prostaglandin E2
UniProt
Immunogen
Human PGE2.
Application Notes
The antibody binds specifically to PGE2, a lipid compound synthesised from the oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2), and from the action of prostaglandin E synthase on prostaglandin H2. PGE2 is an important inflammatory mediator and homeostatic factor that acts on the receptors EP1, EP2 and EP3, which are all members of the family of G-protein coupled receptors (GPCRs). The neutralisation of PGE2 by the use of monoclonal antibodies provides an alternative to the use of NSAIDs in the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis.
Antibody First Published
Shono F, Yokota K, Horie K, Yamamoto S, Yamashita K, Watanabe K, Miyazaki H. A heterologous enzyme immunoassay of prostaglandin E2 using a stable enzyme-labeled hapten mimic. Anal Biochem. 1988 Feb 1;168(2):284-91. PMID:3129960
Note on publication
Describes the development of an enzyme immunoassay for PGE2 utilising an anti- PGE2 antibody, in order to measure the amount of PGE2 present in human urine samples.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
