Cat. No.
MABL-2704
Application
WB, ELISA, FC, IF, IHC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
4G6
From
Recombinant Antibody
Specificity
This antibody recognizes the plasma cell antigen 1.
Alternative Names
PC.1
UniProt
Immunogen
The original version of this antibody was raised by immunizing rats with MRL-lpr/lpr T cells.
Application Notes
The antibody binds specifically to PC.1, an antigen which is highly expressed on the surface of plasma cells and some non-lymphoid tissue. The antigen is involved with secretion or exocytosis of immunoglobulins from B cells, and may play a role in the secretion of lymphokines from lpr/lpr T cells. When the population of this subset of T cells expands, it accumulates in lymph nodes and results lymphadenopathy. Studies have shown that preventing this expansion by performing neonatal thymectomy delays the onset of systemic lupus erythematosus (SLE), suggesting that the T cells play a role in the development of the autoimmune disease. Monoclonal antibodies directed against PC.1 can be useful in the diagnosis and monitoring of SLE.
Antibody First Published
Dumont FJ, Habbersett RC, Coker LZ, Nichols EA, Treffinger JA. High level expression of the plasma cell antigen PC.1 on the T-cell subset expanding in MRL/MpJ-lpr/lpr mice: detection with a xenogeneic monoclonal antibody and alloantisera. Cell Immunol. 1985 Dec;96(2):327-37. PMID:2943419
Note on publication
Describes the generation of the xenogeneic monoclonal antibody 4G6, which reacts strongly with T cells of MRL-lpr/lpr mice that highly express PC.1. This indicates that the T cell subset involved in the development of systemic lupus erythematosus syndrome posses properties of B cells.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
