Cat. No.
MABL-2754
Application
RIA, Block
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
11/32
From
Recombinant Antibody
Specificity
This antibody recognizes and binds progesterone. It also cross reacts with other steroids like 5,α-pregnanedione.
Alternative Names
P4; pregn-4-ene-3,20-dione
UniProt
Immunogen
The original antibody was generated by immunizing BALB/c mice with 11-α- hydroxyprogesterone-11-hemisuccinyl-bovine serum albumin (BSA) conjugate.
Application Notes
This antibody binds progesterone, which is an endogenous steroid female sex hormone, involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. The hormone is produced by the corpus luteum in the ovaries and later by the placenta during pregnancy and is necessary for maintenance of pregnancy as it prevents the breakdown of the endometrium. This antibody against progesterone may be used for the study its role in the female reproductive system and uring pregnancy. It may also be used as an immunological prevention of pregnancy. The antibody is reported to have blocking effects and prevention of pregnancy in mice (PMID：7057905). Passive immunization of mice with this antibody has anti-fertility effects by blocking implantation (PMID：2373979, 3411286). This antibody is also reported to cross react with other steroids (PMID: 3123368, 7632616).
Antibody First Published
Wright et al. Progesterone monoclonal antibody blocks pregnancy in mice. Nature (1982), Issue: 5848, Volume: 295, Page: 415-417. PMID:7057905
Note on publication
Describes the generation and charactierization of the antibody and its role in blocking the establishment of pregnancy in mice.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
