Cat. No.
MABL-2834
Application
Blocking, WB, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Mouse (B1AR), Rat, T. cruzi (TcP2beta), Human
Clone No.
mAb 17.2
From
Recombinant Antibody
Specificity
The antibody binds to the C-terminal region of T. cruzi ribosomal P2beta (epitope: EEEDDDMGFGLFD) and crossreacts with the human beta-1 adrenergic receptor.
Alternative Names
TcP2beta; ADRB1 ; ADRB1R; B1AR; BETA1AR; RHR
UniProt
Q26957
Immunogen
Recombinant TcP2-beta.
Application Notes
This antibody binds to the carbodyl-terminal end of the ribosomal P2-beta protein of T. cruzi, which is part of the Trypanosome ribosome. The antibody cross-reacts with the human beta-1 adrenergic receptor, acting as an agonist.
Antibody First Published
Mahler et al. A monoclonal antibody against the immunodominant epitope of the ribosomoal P2beta protein of Trypanosoma cuzi interacts with the human beta 1-adrenergic receptor. European Journal of Immunology 2001; 31(7):2210-2216 PMID:11449375
Note on publication
Describes the generation of murine antibodies against ribosomal P2beta of T. cruzi, showing evidence that it cross-reacts with human beta1-adrenergic receptor.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
