Cat. No.
MABL-2844
Application
WB, ELISA, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AbAb-ROR1
From
Recombinant Antibody
Specificity
This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.
Alternative Names
NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1
UniProt
Q01973
Immunogen
The original antibody was generated by immunizing mice with recombinant human ROR1.
Application Notes
This antibody can recognize recombinant human ROR1 protein in an ELISA. This antibody was capable of detecting human ROR1 from A2780 and Iose386 cell lysates in a western blot. The binding of this antibody to ROR1 expressed on the surface of human ovarian cancer A2780 and Iose386 cells was determined using flow cytometry. It was reported that this antibody can also effectively bind and detect human ROR1 in immunofluorescent staining of human ovarian cancer cell A2780 and Iose386 cells (CN107827984).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
