Cat. No.
MABL-2871
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
3-D7
From
Recombinant Antibody
Specificity
This antibody binds human and mouse sclerostin. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain which is produced in osteocytes (type of bone cell). The glycoprotein sclerostin has been identified as a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Neutralizing anti-sclerostin antibodies are able to restore Wnt activity and enhance bone growth thereby presenting a new osteoanabolic therapy approach for diseases such as osteoporosis.
Alternative Names
SOST
UniProt
Q9BQB4; Q99P68
Immunogen
The original antibody was generated by immunizing four alpacas with recombinant human sclerostin.
Application Notes
The binding reactivity of this antibody for human and mouse sclerostin was determined using ELISA (WO2010130830).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
