Cat. No.
MABL-3068
Application
IP, WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Bovine, Human
Clone No.
aThy-23
From
Recombinant Antibody
Specificity
Alternative Names
Tg
UniProt
P01267
Immunogen
Human thyroglobulin.
Application Notes
The antibody binds specifically to thyroglobulin, a dimeric protein produced by the follicular cells of the thyroid gland. Thyroglobulin is the precursor of the thyroid hormone thyroxine (T4) and triiodothyronine (T3). Levels of thyroglobulin in the blood can be used as markers for certain thyroid tumours, and these levels can sometimes be masked by the presence of thyroglobulin antibodies, which are found most commonly in patients with Hashimoto's thyroiditis and Grave's disease. The detection of anti-Tg antibodies can therefore be used to test for these diseases.
Antibody First Published
Griffiths AD, Malmqvist M, Marks JD, Bye JM, Embleton MJ, McCafferty J, Baier M, Holliger KP, Gorick BD, Hughes-Jones NC, et al. Human anti-self antibodies with high specificity from phage display libraries. EMBO J. 1993 Feb;12(2):725-34. PMID:7679990
Note on publication
Describes the potential of human monoclonal antibodies in developing new therapies, and the advantages of using phage antibody technology in comparison to the hybridoma technology. Also describes the production of several; scFVs using phage display libraries, against human TNF alpha, thyroglobulin, MUC1, Fog1 and CD4.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
