Cat. No.
MABL-3132
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
679-14-E06
From
Recombinant Antibody
Specificity
The antibody binds to the N-terminal region of TG2 with a Kd of 55 nM.
Alternative Names
TG2; Protein-Glutamine gamma-Glutamyltransferase 2
UniProt
P21980
Immunogen
Autoantigen TG2.
Application Notes
This antibody binds to human Transglutaminase 2, an enzyme that catalyzes the isopeptide bond formation between an amine group and an acyl group at the end of the side chain of a glutamine. Anti-TG2 antibody are found in celiac disease and high levels of transglutaminase are found in Huntington's and Parkinson's.
Antibody First Published
Chen et al. Structural basis for antigen recognition by transglutaminase 2- specific autoantibodies in celiac disease. Journal of Biological Chemistry 2015; Manuscript M115.669895 PMID:26160175
Note on publication
Describes autoantibodies against TG2 and crystallisation as well as molecualar dynamic simulations.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
