Cat. No.
MABL-3175
Application
Blocking, WB
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
mAb-112
From
Recombinant Antibody
Specificity
The antibody binds to pro-uPA with a Kd of 0.8E-9M.
Alternative Names
pro-uPA; urokinase zymogen
UniProt
P00748
Immunogen
Human recombinant single chain pro-uPA.
Application Notes
The antibody binds to and stabilizes pro-uPA, the zymogen form (inactive) of urokinase-type plasminogen activator. Active uPA catalyzes the conversion of plasminogen to the active protease plasmin, a protease that degrades extracellular matrix proteins. T
Antibody First Published
Blouse et al. 2009 A novel mode of intervention with serine protease activity:targeting zymogen activation. Journal of Biological Chemistry 2009; 284(7):4647-4657 PMID:19047064
Note on publication
Describes the generation of a monoclonal antibody that binds to pro-uPA with subnanomolar affinity.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
