Key features and details | |
Cat. No. | MABL-1230 |
Name | Anti-CNPS mAbs |
Clone No. | AFD-3E 5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Cryptococcus neoformans |
Basic Information | |
Specificity | Specifically binds to CNPS. |
Alternative Name | CNPS; Cryptococcus neoformans capsular polysaccharide; glucuronoxylomannan |
UniProt | |
Immunogen | A covalent serotype A Glucuronoxylomannan (GXM) -tetanus toxoid conjugate (GXM-TT). |
Application Notes | This antibody binds to Glucuronoxylomannan (GXM), which is the main constituent of the C. neoformans capsule and modulates the inflammatory response of monocytes. In a later study conducted by Yuan et al. 1998 (PMID: 9488395), it was shown that switching the original murine IgG3 antibody to other IgG subtypes, in particular IgG2A, significantly prolonged animal survival in an infection model. |
Antibody First Published | Casadevall et al. 1992 Antibodies elicited by a Cryptococcus neoformans- tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. Journal of Infectious Diseases 1992; 165(6):1086-1093 PMID:1583327 |
Note on publication | Describes the generation of nine monoclonal antibodies from the spleen of a GXM- TT-immunized mouse. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
