Key features and details | |
Cat. No. | MABL-1766 |
Name | Anti-H4K20me3 mAbs |
Clone No. | AFD- 20F109 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is capable of recognizing histone H3 proteins with a trimethylation at Lys20. Methylation is a type of post-translational modification (PTM) which is caused by covalent addition of methyl group to proteins, DNA or other molecules. PTMs have fundamental roles in chromatin structure and function. The PTMs that have taken place in histone proteins can affect gene expression by altering chromatin structure. Histone modifications have also been known as epigenetic markers. Defects in the PTMs pathway have been associated with the occurrence and progression of various human diseases, such as cancer, heart failure, autoimmune diseases, and neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and Huntington's disease. |
Alternative Name | Trimethylated Histone H4 Lys20; trimethyl-Histone H4 (Lys20); histone H4; H4K20; Trimethylated histone H4; Histone H4 trimethylated at Lysine 20; nucleosome; H4K20ME3; post translational modification; histone post-translational modification |
UniProt | |
Immunogen | |
Application Notes | This antibody can be used to detect histone H4 proteins trimethylated at lysine 20 (H4K20me3) using ELISA (US10208110). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
