Key features and details | |
Cat. No. | MABL-2224 |
Name | Anti-LAG3 mAbs |
Clone No. | AFD- AbAbLAG3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vitro, inhibit, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for LAG3. Lymphocyte activation gene 3 protein is an inhibitory receptor on antigen activated T-cells. It delivers inhibitory signals upon binding to ligands, such as FGL1. |
Alternative Name | Lymphocyte-activation gene-3; Lymphocyte activation gene 3 protein; CD223; LAG-3; CGMCNO 20774 |
UniProt | P18627 |
Immunogen | The original antibody was generated by immunizing transgenic HuMab or KM mice with recombinant human LAG-3 protein. |
Application Notes | The binding characterization of this antibody to human LAG3-Fc fusion protein was done using ELISA. The original human IgG antibody was reported to bind human LAG-3 in the sub picomolar range. This antibody was effective in inhibiting the binding of LAG3 to MHC class II molecules in an in vitro binding assay. In the antigen-specific T cell response assay, this antibody can stimulate the production of IL- 2 (CN109748963). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
