Key features and details | |
Cat. No. | MABL-2283 |
Name | Anti-LTC4 mAbs |
Clone No. | AFD- mAbLTC |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, Block, ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | The antibody binds to LTC4 with an EC50 of 0.11 μM. |
Alternative Name | Leukotriene C4 |
UniProt | |
Immunogen | Human LTC4. |
Application Notes | The antibody binds specifically to LTC4, a member of eicosanoid inflammatory mediators synthesised from arachidonic acid by arachidonate 5-lipoxygenase. LTC4 is a cysteynyl- leukotriene, and acts at the cell-surface receptors CysLT1 and CysLT2, which are both G-protein coupled receptors (GPCRs) involved in human bronchial asthma. LTC4 is responsible for increasing airway responsiveness to histamine in asthmatic patients, and antibodies that block this activity can be used in the treatment of inflammatory diseases such as asthma, and to inhibit platelet aggregation. |
Antibody First Published | Matsumoto S1, Hayashi Y, Kinoshita I, Ikata T, Yamamoto S.. Immunoaffinity purification of prostaglandin E2 and leukotriene C4 prior to radioimmunoassay: application to human synovial fluid. Ann Clin Biochem. 1993 Jan;30 ( Pt 1):60-8. PMID:20079714 |
Note on publication | Describes the synthesis of a monoclonal antibody specific for LTC4 and its use in immunoassays to detect the amount of LTC4 in synovial fluid from patients with rheumatoid arthritis, osteoarthritis and other joint diseases. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
