Key features and details | |
Cat. No. | MABL-2631 |
Name | Anti-PD-1 mAbs |
Clone No. | AFD- 11F5C5 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds the extracellular domain of the human PD-1. PD-1 is an immunosuppressive receptor having a molecular weight of 50 to 55 kD, a type 1 transmembrane glycoprotein belonging to immunoglobulin CD28 / CTLA-4 family members. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. It delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. |
Alternative Name | CD279; PD1; PD 1; hPD-1; PDCD1; Programmed cell death protein 1; Programmed cell death 1; Protein PD-1; CGMCC NO.16209; NAT105 |
UniProt | Q15116 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with recombinant human PD-1 protein comprising amino acids 32-160. |
Application Notes | This antibody is highly similar to the commercially available anti-PD-1 antibody NAT105. The binding specificity of this antibody towards human PD-1 was determined using ELISA. The original IgG2a antibody binds human PD_1 with an affinity constant of 7.13X10^9 M^(-1). This antibody is capable of detecting human PD-1 in a western blot assay. This antibody was used in the immunohistochemical staining of samples of T cell lymphomas and B cell lymphomas (CN109293775). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
