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Anti-PD-1 mAbs

简要描述:

This antibody recognizes an epitope on mouse PD-1.

产品参数:

Cat. No.:MABL-2634

Species:Engineer

Species Reactivity:Mouse

Type:Recombinate

Application:Blocking, IHC, WB, FC

详细介绍

Key features and   details


Cat. No.

MABL-2634

Name

Anti-PD-1 mAbs

Clone No.

AFD- 29F.1A12

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, IHC, WB, FC

Species Reactivity

Mouse

Basic Information


Specificity

This antibody recognizes an epitope on mouse   PD-1.

Alternative Name

CD279; Programmed cell death protein 1;   Protein PD-1; mPD-1

UniProt

Q02242

Immunogen

The antibody was raised by immunizing rats with   plasmid DNA containing PD-1.

Application Notes

This antibody was used for detection of PD-1   in CHO cells using flow cytometry. The ability of the antibody to block PD-1   interaction with PD-L1 or PD-L2 on CHO cells in an in vitro blocking assay   was tested; the clone blocked PD-L1 Ig and PD-L2 Ig binding at high   concentration, but only blocked 35% of PD-L1 Ig or PD-L2 Ig binding at 10   ug/ml. This antibody was also used for immunohistochemical studies of various   mouse tissues, such as heart (Liang et al, 2003; pmid: 14515254). In vivo   anti-tumor effect in terms of level of tumor growth reduction was studied, a   significant tumor growth reduction was observed in the tumors from mice   treated with the antibody (Tobias et al, 2020; pmid: 32528470). The antibody   was used for the detection of PD-1 in EL4 cells using flow cytometry. The   antibody was used for cross-blocking with the unconjugated version of the   same clones and it was reported to prevent PD-1 from interacting with PD-L1   (Polesso et al, 2021; pmid: 33684223). 

Antibody First   Published

Liang et al. Regulation of PD-1, PD-L1, and   PD-L2 expressionduring normal and autoimmune response Eur. J. Immunol. 2003.   33: 2706–2716 PMID:14515254

Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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