Key features and details | |
Cat. No. | MABL-3200 |
Name | Anti-VEGFR2 mAbs |
Clone No. | AFD- B1A1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | SPR |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for VEGFR2. |
Alternative Name | flk-1;FLK-1; KDR; Fetal liver kinase 1; Kinase ｉｎｓｅｒｔ domain receptor; Protein-tyrosine kinase receptor; EC:2.7.10.1; Vascular endothelial growth factor receptor 2; Vascular endothelial growth factor receptor |
UniProt | P35968 |
Immunogen | The original antibody was isolated by panning a phage display library against VEGFR2. |
Application Notes | The bispecific antibody (A1-A8)-LALA associated with either VEGFR2 or PDLl fast and stayed on either VEGFR2 or PDLl long (KD values of BsAb (A1-A8) were about 200 pM and 3.2 pM for the hVEGFR2 and hPDLl). A cytokine secretion assay was carried out with the bispecific antibody and B1A1. The results indicate that in the present of BsAb (A1-A8)-LALA, the secretion of cytokine IL2 and INFy in PBMC when stimulated by SEB was higher than the control antibody B1A1, demonstrating that BsAb (A1-A8)-LALA retains the potency of its parental antibody B1A1 (against VEGFR2) and dsD7A8-LALA (against PDL1) (EP3411068A4). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
