Name
FCGRT Mouse
Cat. No.
MAG-6157
Tag/Conjugates
His
Source
Sf9, Baculovirus cells.
Shipped
Shipped with Ice Packs
Description
FCGRT Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 285 amino acids (22-297 a.a) and having a molecular mass of 32.1kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). FCGRT is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Synonyms
IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt, Fcrn.
Introduction
Fc Fragment Of IgG Receptor And
Transporter also known as FCGRT is a transmembrane glycoprotein with structural
homology to MHC class 1 proteins. FCGRT is widely expressed in endothelial and
epithelial cells and takes a vital part in IgG homeostasis. Moreover, FCGRT is expressed
in neutrophils in addition myeloid antigen presenting cells. FCGRT can enhance
IgG-meditated phagocytosis as well as antigen presentation by heses cells, however
it promotes the degradation of opsonizing IgG rather than returning it to the
circulation.
Physical Appearance
Sterile filtered colorless solution.
Formulation
FCGRT protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
ADP SETRPPL MYHLTAVSNP STGLPSFWAT GWLGPQQYLT YNSLRQEADP CGAWMWENQV SWYWEKETTD LKSKEQLFLE ALKTLEKILN GTYTLQGLLG CELASDNSSV PTAVFALNGE EFMKFNPRIG NWTGEWPETE IVANLWMKQP DAARKESEFL LNSCPERLLG HLERGRRNLE WKEPPSMRLK ARPGNSGSSV LTCAAFSFYP PELKFRFLRN GLASGSGNCS TGPNGDGSFH AWSLLEVKRG DEHHYQCQVE HEGLAQPLTV DLDSSARSS H HHHHH.
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
