Name
SCO1 Human
Cat. No.
MAG-6553
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
Shipped with Ice Packs
Description
SCO1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 179 amino acids (132-301 a.a) and
having a molecular mass of 20.5kDa. SCO1 is fused to a 9 amino acid His-tag at C-terminus
& purified by proprietary chromatographic techniques.
Synonyms
SCO1 Cytochrome C Oxidase Assembly Protein, SCOD1, SCO
(Cytochrome Oxidase Deficient, Yeast) Homolog 1, SCO Cytochrome Oxidase
Deficient Homolog 1 (Yeast), SCO Cytochrome Oxidase Deficient Homolog 1, Protein
SCO1 Homolog, Mitochondrial, SCOD1, Protein SCO1 homolog, mitochondrial.
Introduction
SCO Cytochrome Oxidase Deficient Homolog 1, also known as SCO1 is a
member of the SCO1/2 family. Mammalian cytochrome c oxidase (COX) catalyzes the
transfer of reducing equivalents from cytochrome c to molecular oxygen and
pumps protons across the inner mitochondrial membrane. Furthermore, in yeast, two
related COX assembly genes, SCO1 & SCO2 which are synthesis of cytochrome c
oxidase, enable subunits 1 as well as 2 to be incorporated into the
holoprotein. This gene is the human homolog to the yeast SCO1 gene. Among the diseases
associated with SCO1 are hepatic failure, early-onset, neurologic disorder due
to cytochrome c oxidase deficiency and fatal infantile cytochrome c oxidase
deficiency.
Physical Appearance
Sterile filtered colorless solution.
Formulation
SCO1 protein solution (1mg/ml) containing Phosphate
buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 95% as determined by SDS-PAGE.
Amino acid sequence
MGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM
IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA YRVYYSPGPK
DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK SL EHHHHHH .
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
