Name
THBS4 Mouse
Cat. No.
MAG-6662
Tag/Conjugates
His
Source
HEK293 Cells.
Shipped
Shipped with Ice Packs
Description
THBS4 Mouse Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 943 amino acids (27-963a.a) and having a molecular mass of 104.3 kDa. THBS4 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Synonyms
THBS4, Thbs4, Thbs-4, Thrombospondin-4, Thrombospondin4, thrombospondin 4, Tsp4, TSP-4, TSP, TSP4, TS.
Introduction
Thrombospondin-4 (THBS4) is a member of the thrombospondin protein family. This family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. THBS4forms a pentamer and binds to heparin and calcium. Among them THBS4binds a variety of matrix proteins including Collagens I, II, III, V, Laminin‑1, Matrilin‑2 and Fibronectin. THBS4 is up‑regulated in the spinal cord following peripheral nerve injury where it contributes to presynaptic hypersensitivity and hyperalgesia and is also up‑regulated in muscle following denervation.
Physical Appearance
Sterile filtered colorless solution.
Formulation
The THBS4 solution (0.25mg/1ml) contains phosphate buffered saline (pH7.4), 0.1mM PMSF and 20% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
QATPQVFDLL PSSSQRLNPS ALQPVLTDPT LHEVYLISTF KLQSKSSATI FGLYSSSDNS KYFEFTVMGR LNKAILRYLK NDGKIHLVVF NNLQLADGRR HRVLLRLSNL QRGDGSVELY LDCAQADSVR NLPRAFSGLT QNPESIELRT FQRKPQDFLE ELKLVVRGSL FQVASLQDCF LQQSEPLAAT STGDFNRQFL GQMTQLNQLL GEVKDLLRQQ VKETSFLRNT IAECQACGPL SFQSPTPNTL VPIAPPAPPT RPTRHCDSSP CFRGVRCTDT RDGFQCGPCP DGYTGNGITC SDVDECKYHP CYPGVRCVNL APGFRCDACP VGFTGPMVQG VGINFAKTNK QVCTDVDECQ NGACVLNSIC INTLGSYRCG PCKPGYTGDQ TRGCKTERSC RNPEQNPCSV HAQCIEERQG DVTCVCGVGW AGDGYVCGKD VDIDSYPDEE LPCSARNCKK DNCKYVPNSG QEDADRDGIG DACDEDADGD GILNEQDNCV LTHNIDQRNS DKDIFGDACD NCRMVLNNDQ KDTDGDGRGD ACDDDMDGDG IKNILDNCPR VPNRDQQDRD GDDVGDACDS CPDVSNPNQS DVDNDLVGDS CDTNQDSDGD GHQDSTDNCP TVINSSQLDT DKDGIGDECD DDDDNDGIPD LVPPGPDNCR LVPNPAQEDS NNDGVGDICE ADFDQDQVID HIDVCPENAE ITLTDFRAYQ TVVLDPEGDA QIDPNWVVLN QGMEIVQTMN SDPGLAVGYT AFNGVDFEGT FHVNTQTDDD YAGFIFGYQD SSSFYVVMWK QTEQTYWQAT PFRAVAEPGI QLKAVKSKTG PGEHLRNSLW HTGDTSDQVR LLWKDSRNVG WKDKVSYRWF LQHRPQVGYI RVRFYEGSEL VADSGVTIDT TMRGGRLGVF CFSQENIIWS NLKYRCNDTI PEDFQEFQTQ SFDRLDN HHH HHH
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
