Name
RARRES2 Human
Cat. No.
MAG-6920
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
At Room Temperature
Description
RARRES2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 138 amino acids and having a total molecular mass of 16 kDa. RARRES2 Human Recombinant is purified by proprietary chromatographic techniques.
Synonyms
Chemerin, TIG2, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
Introduction
RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
The RARRES2 protein was lyophilized from 0.02% TFA.
Stability
Lyophilized Chemerin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Chemerin should be stored at 4°C between 2-7 days and for future use below -18°C._x000D_
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA)._x000D_
Please prevent freeze-thaw cycles.
Purity
Greater than 98.0% as determined by:_x000D_
(a) Analysis by RP-HPLC._x000D_
(b) Analysis by SDS-PAGE.
Amino acid sequence
MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAAVDTP FPAGIFVRLE FKLQQTSRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS.
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
