Name
ZFAND5 Human
Cat. No.
MAG-7396
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
Shipped with Ice Packs
Description
ZFAND5 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 236 amino acids (1-213 a.a) and having a molecularmass of 25.5kDa (Molecular size on SDS-PAGE will appear higher). ZFAND5 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
Synonyms
Zinc Finger, AN1-Type Domain 5, Zinc Finger Protein 216, ZNF216,Zinc Finger A20 Domain-Containing Protein 2, Zinc Finger, A20 Domain Containing2, ZA20D2, AN1-Type Zinc Finger Protein 5, ZFAND5A, AN1-type zinc fingerprotein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216.
Introduction
Zinc Finger, AN1-Type Domain 5, also known as ZFAND5 is implicated inprotein degradation through the ubiquitin-proteasome system. ZFAND5 performs byanchoring ubiquitinated proteins to the proteasome and takes part inubiquitin-mediated protein degradation during muscle atrophy. Furthemore,ZFAND5 plays a role in the regulation of NF-kappa-B activation as well asapoptosis. ZFAND5 inhibits NF-kappa-B activation as well as tumor necrosisfactor (TNF), IL-1 and TLR4-induced NF-kappa-B activation.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
ZFAND5 protein solution (0.5mg/ml) containing 20mM Phosphatebuffer saline (pH 8.0), 30% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGS MAQETNQ TPGPMLCSTG CGFYGNPRTN GMCSVCYKEH LQRQQNSGRMSPMGTASGSN SPTSDSASVQ RADTSLNNCE GAAGSTSEKS RNVPVAALPV TQQMTEMSIS REDKITTPKTEVSEPVVTQP SPSVSQPSTS QSEEKAPELP KPKKNRCFMC RKKVGLTGFD CRCGNLFCGL HRYSDKHNCPYDYKAEAAAK IRKENPVVVA EKIQRI.
Safety Data Sheet
SDS
Usage
Mabioway
