Anti-MERS-CoV Spike Protein mabs [4c2](MABL-3586)

Cat. No.

MABL-3586

Name

Anti-MERS-CoV Spike Protein mabs [4c2](MABL-3586)

Clone No.

4c2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

crystallization, NTRL, ELISA

Species Reactivity

MERS-CoV

Basic Information

Specificity

This antibody binds MERS-CoV spike protein at an epitope overlapping with the receptor- binding domain (MERS-RBD).

Alternative Name

MERS-RBD; Middle East respiratory syndrome coronavirus spike

UniProt

Immunogen

Recombinant spike receptor-binding domain of MERS-CoV prepared from insect High5 cells.

Application Notes

This antibody binds to MERS-RBD and blocks virus entry in vitro with high efficacy by both steric hindrance and   interface-residue competition.

Antibody First   Published

Li et al. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein  Cell Research 25, 1237-1249 PMID:26391698

Note on publication

Describes the generation as well as functional and structural characterization of this antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.