Cat. No.
MABL-023
Application
Blocking, SPR, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MNAC13
From
Recombinant Antibody
Specificity
This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.
Alternative Names
Tropomyosin Receptor Kinase; NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; neurotrophic receptor tyrosine kinase 1; High Affinity Nerve Growth Factor Receptor; Tyrosine Kinase Receptor A
UniProt
P04629
Immunogen
Human TrkA ECD.
Application Notes
This antibody binds to human TrkA, a receptor tyrosine kinase involved in the development and the maturation of the CNS and the PNS through regulation of proliferation, differentiation, and survival of the sympathetic and nervous neurons. It is a receptor for NGF and phosphorylates several downstream proteins regulating a variety of signalling cascades. This antibody neutralizes the NGF-TrkA interation.
Antibody First Published
Covaceuszach et al. Neutralization of NGR-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: A strcutural insight. Proteins 2005; 58(3):717- 727 PMID:15625712
Note on publication
Describes the characterisation of an antibody against human TrkA and demonstration of its neutralizing activity.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
