Cat. No.
MABL-022
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Fab-IDE
From
Recombinant Antibody
Specificity
Binds specificially to human IDE with a Kd of 3.72 nM.
Alternative Names
IDE; Insulin Protease
UniProt
P14735
Immunogen
Human IDE.
Application Notes
This antibody binds human insulin degrading enzyme, which breaks down insulin as well as amyloid peptides and is suggested to play a role in both diabetes and Alzheimer's. Antibody binding does not affect steady-state kinetics of IDE.
Antibody First Published
McCord et al. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the USA 2013; 110(34):13827-13832 PMID:23922390
Note on publication
Describes the generation of an antibody against human IDE and crystallisation of the complex.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
