Cat. No.
MABL-185
Application
IF
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
N8B/1R
From
Recombinant Antibody
Specificity
This antibody is specific for the Cavbeta2 Ca2+ channel antigen. It does not cross-react with Cavβ1, Cavβ3, Cavβ4. The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Alternative Names
Calcium channel voltage-dependent subunit beta 2; Cacnb2; Voltage- dependent L-type calcium channel subunit beta-2; N8B/1
UniProt
A0A0G2JSZ0
Immunogen
This antibody was raised by immunizing a mouse with the rat Cavbeta2 Ca2+ channel antigen.
Application Notes
Immunofluorescence was preformed with this antibody on neurons from mice (Held et al, 2020; PMID:32616470). This antibody was used for immunofluorescence on rat neurons (Ortiz-miranda et al, 2010; PMID:20509142).
Antibody First Published
Ortiz-Miranda et al. Differential Modulation of N-Type Calcium Channels by m-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals J Cell Physiol. 2010 Oct;225(1):276-88. PMID:20509142
Note on publication
The underlying basis for AVP’s weaker inhibition by MOR activation is described and a more complete explanation of the complicated effects on neuropeptide release is provided.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
