Cat. No.
MABL-186
Application
WB, IF
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
L28/4R
From
Recombinant Antibody
Specificity
This antibody is specific for the Kv4.2 potassium channel antigen. This protein is a voltage- gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. It mediates the major part of the dendritic A-type current I(SA) in brain neurons.
Alternative Names
Potassium voltage-gated channel subfamily D member 2; Kcnd2; RK5; Shal1; Voltage-gated potassium channel subunit Kv4.2; L28/4
UniProt
Q63881
Immunogen
This antibody was raised by immunizing a mouse with fusion protein amino acids 471-630 (cytoplasmic C-terminus) of rat Kv4.2.
Application Notes
Immunofluorescence was preformed on Cells expressing DPPX-S, Kv4.2, and/or KChIPs with this antibody (Seikel and Trimmer, 2009; PMID:19441798). Cardiac myocytes from mice were immunostained with this antibody (Kilfoil et al, 2019; PMID:31639389). Mouse left ventricular tissue lysates were immunoblotted with this antibody (Kilfoil et al, 2019; PMID:31639389).
Antibody First Published
Seikel and Trimmer Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits Biochemistry. 2009 Jun 23;48(24):5721-30.
PMID:19441798
Note on publication
The convergent roles that DPPX-S and KChIPs play as component subunits of Kv4.2 channel complexes were characterized.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
