Cat. No.
MABL-327
Application
Block
Isotype
Engineer antibody
Species Reactivity
n/a
Clone No.
409.5.3
From
Recombinant Antibody
Specificity
Alternative Names
733.1.4 idiotype;E2 specific feline infectious peritonitis virus-neutralizing antibody (anti-idiotype)
UniProt
Immunogen
Monoclonal antibody 730.1.4.
Application Notes
The antibody binds specifically to the antibody 730.1.4, which neutralises feline infectious peritonitis virus (FIPV). The FIPV virus causes a fatal disease that affects cats by its ability to invade and grow in macrophages, which causes an inflammatory response in the infected tissue. When injected into mice, the antibody 409.5.3 has been shown to elicit the production of 730.1.4 antibodies, thereby indirectly neutralising the virus.
Antibody First Published
Escobar JC, Kochik SA, Skaletsky E, Rosenberg JS, Beardsley TR. Immunization of cats against feline infectious peritonitis with anti-idiotypic antibodies. Viral Immunol. 1992 Spring;5(1):71-9. PMID:1319173
Note on publication
Describes the characterisation of the anti-idiotypic monoclonal antibody 409.5.3, which is raised against an antibody that neutralises feline infectious peritonitis virus.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
