Cat. No.
MABL-542
Application
Blocking, ELISA
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
V3-46s
From
Recombinant Antibody
Specificity
This antibody is specific for the BR3 protein.
Alternative Names
Tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; B- cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268
UniProt
Q96RJ3
Immunogen
The original antibody was generated from a synthetic antibody library that was built on a single human framework by introducing synthetic diversity at solvent-exposed positions within the heavy chain complementarity-determining regions.
Application Notes
This antibody was used for ELISA on mBR3-ECD and hBR3-ECD (US20080181888). This antibody blocks BAFF-BR3 binding (US20080181888). The Fab version of this antibody bound mouse BR3- ECD and human BR3-ECD with an affinity of 1nM and 0.6nM respectively. Humanized V3-46s antibody also blocked BAFF binding to BR3 on BJAB cells and bound BR3 on BJAB cells. This antibody was used as a template to make homolog shotgun libraries (US20080181888).
Antibody First Published
Ambrose et al. Polypeptides That Bind Br3 and Uses Thereof. US20080181888
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
