Cat. No.
MABL-975
Application
in vivo
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
BIWA8
From
Recombinant Antibody
Specificity
The antibody is specific for CD44v6. CD44v6 is a tumor associated antigen abundantly expressed in head and neck squamous cell carcinomas (HNSCC) and in normal squamous epithelium.
Alternative Names
CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I
UniProt
P16070
Immunogen
The antibody is the humanized version of the murine BIWA-1.
Application Notes
The antibody is the mutated version of BIWA-4 that was constructed with the aim of improving binding affinity. The binding affinity of the antibody to CD44v6 was measured by surface plasmon resonance. The antibody showed a specificity of tumor localization when administrated together with another anti-CD44v6 antibody to mice in in vivo experiments (Verel et al. 2002; PMID: 11992408). The specificity of the humanized version of the antibody was confirmed by ELISA anlaysis (Kd= 0.84 nM). The antibody had good therapeutic efficacy in in vivo experiments in mice. Mice treated with labelled 186Re- BIWA 8 showed a decreased in the tumor volume (US6972324B2).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
