Cat. No.
MABL-1003
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AbAbCD47
From
Recombinant Antibody
Specificity
This antibody binds the extracellular domain of the human CD47, which is broadly distributed on normal adult tissues, as well as ovarian tumors, and is especially abundant in some epithelia and the brain. IAP or integrin associated protein has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It further plays an important role in memory formation and synaptic plasticity in the hippocampus. It also acts as a receptor for SIRPA. Binding to SIRPA prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Alternative Names
IAP; MER6; OV-3; Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein; Protein MER6; ovarian cancer marker
UniProt
Q08722
Immunogen
The original antibody was generated by immunizing a dromedary with recombinant human CD47. The peripheral blood cells of the camel were used to generate nanobody library and the particular clone was isolated by screening the library against human CD47.
Application Notes
The binding ability of this antibody for extracellular human CD47 polypeptide was determined using ELISA (WO2016188449).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
