Cat. No.
MABL-1230
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Cryptococcus neoformans
Clone No.
3E 5
From
Recombinant Antibody
Specificity
Specifically binds to CNPS.
Alternative Names
CNPS; Cryptococcus neoformans capsular polysaccharide; glucuronoxylomannan
UniProt
Immunogen
A covalent serotype A Glucuronoxylomannan (GXM) -tetanus toxoid conjugate (GXM-TT).
Application Notes
This antibody binds to Glucuronoxylomannan (GXM), which is the main constituent of the C. neoformans capsule and modulates the inflammatory response of monocytes. In a later study conducted by Yuan et al. 1998 (PMID: 9488395), it was shown that switching the original murine IgG3 antibody to other IgG subtypes, in particular IgG2A, significantly prolonged animal survival in an infection model.
Antibody First Published
Casadevall et al. 1992 Antibodies elicited by a Cryptococcus neoformans- tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. Journal of Infectious Diseases 1992; 165(6):1086-1093 PMID:1583327
Note on publication
Describes the generation of nine monoclonal antibodies from the spleen of a GXM- TT-immunized mouse.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
