Cat. No.
MABL-1410
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Species independent
Clone No.
06CT8.1.1.1
From
Recombinant Antibody
Specificity
This antibody binds maytansine (DM1), a thiol-containing maytansinoid which is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate (ADC), for the selective delivery of the drug and destruction of cancer cells. ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine.
Alternative Names
Mertansine; Maytansinoid
UniProt
Immunogen
The original antibody was generated by immunizing BALB/c mice with DM1-cysteine-KLH conjugate.
Application Notes
The binding reactivity of this antibody towards BSA-DM1 was determined using ELISA. This antibody is recommended for detection of antibody-drug conjugates containing DM1 (CN114276448).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
