Cat. No.
MABL-1720
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
SE
From
Recombinant Antibody
Specificity
This antibody binds the glycoprotein GPIIb/IIIa complex (CD41/CD61 complex). The GPIIb/IIIa is a heterodimeric complex formed after synthesis of one lib and one Ilia subunit. The principal ligand for GPIIb/IIIa is fibrinogen, but it also binds to fibronectin, von Willebrand factor, vitronectin, thrombospondin and CD40 ligand. The binding between GPIIb/IIIa and fibrinogen dimers leads to platelet aggregation and thrombus formation, and this is possible only when the receptor adopts its activated conformation.
Alternative Names
GPIIb/IIIa; CD41/CD61; integrin allb83
UniProt
P08514
Immunogen
The original antibody was generated by screening human scFv antibody libraries.
Application Notes
The antibody bound to activated platelets and inhibited platelet activation. This antibody was used for detection of activated platelets by flow cytometry (WO2020237304).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
