Cat. No.
MABL-1721
Application
WB, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Ab01TIGIT
From
Recombinant Antibody
Specificity
This antibody binds the glycosylated form of the human TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. It is an immune receptor present on some T cells and natural killer cells (NK). It binds the poliovirus receptor (PVR) with high affinity which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Alternative Names
VSTM3; VSIG9; WUCAM; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; post translational modification
UniProt
Q495A1
Immunogen
The original antibody was generated by immunizing BALB/c mice with glycosylated human TIGIT protein.
Application Notes
The binding characterization of this antibody towards was done using ELISA. This antibody is also capable of recognizing TIGIT expressed on CD8+ and CD4+ cell lysates in an western blot assay (CN111705066).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
