Cat. No.
MABL-1766
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
20F109
From
Recombinant Antibody
Specificity
This antibody is capable of recognizing histone H3 proteins with a trimethylation at Lys20. Methylation is a type of post-translational modification (PTM) which is caused by covalent addition of methyl group to proteins, DNA or other molecules. PTMs have fundamental roles in chromatin structure and function. The PTMs that have taken place in histone proteins can affect gene expression by altering chromatin structure. Histone modifications have also been known as epigenetic markers. Defects in the PTMs pathway have been associated with the occurrence and progression of various human diseases, such as cancer, heart failure, autoimmune diseases, and neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and Huntington's disease.
Alternative Names
Trimethylated Histone H4 Lys20; trimethyl-Histone H4 (Lys20); histone H4; H4K20; Trimethylated histone H4; Histone H4 trimethylated at Lysine 20; nucleosome; H4K20ME3; post translational modification; histone post-translational modification
UniProt
Immunogen
Application Notes
This antibody can be used to detect histone H4 proteins trimethylated at lysine 20 (H4K20me3) using ELISA (US10208110).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
