Cat. No.
MABL-1903
Application
Block, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
hGR-2 F6
From
Recombinant Antibody
Specificity
The antibody binds to the human glucagon receptor.
Alternative Names
hGR
UniProt
P47871
Immunogen
Recombinant human glucagon receptor.
Application Notes
This antibody binds to the human glucaon receptor, a GPCR that is activated by glucagon and stimulates adenylate cyclase. The receptor is involved in glucose homeostasis and regulats glucose production in the liver. The antibody acts as a competitive antagonist.
Antibody First Published
Wight et al. Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor. Acta Crystallography Section D Biological Crystallography 2000; 56(5)573-580 PMID:10771426
Note on publication
Describes the crystallisation of mAb hGR-2 F6 with the glucagon receptor and subsequent binding- and inhibition studies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
