Cat. No.
MABL-1932
Application
ICC, WB, Block, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AF2
From
Recombinant Antibody
Specificity
The antibody binds to IFNγ with an IC50 of 65 pM and an affinity (Kd) of 19.3 nM.
Alternative Names
Interferon gamma; Immune interferon ; IFN-gamma; IFNG
UniProt
P01579
Immunogen
Human IFNγ.
Application Notes
The antibody binds specifically to IFNγ, a dimerised soluble cytokine member of the type II class of interferons synthesised by activated T-lymphocytes and natural killer (NK) cells. . IFNγ plays a role in both the innate and adaptive immune responses, an
Antibody First Published
Thakur AB, Landolfi NF. A potent neutralizing monoclonal antibody can discriminate amongst IFNγ from various primates with greater specificity than can the human IFNγ receptor complex. Mol Immunol. 1999 Oct-Nov;36(15-16):1107-15. PMID:10698312
Note on publication
Describes the generation of the anti-IFNγ monoclonal antibody AF2, and its ability to neutralise the activity of IFNγ in humans compared to other primates.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
