Cat. No.
MABL-2071
Application
crystallisation
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
Ab2
From
Recombinant Antibody
Specificity
This antibody binds both human and murine IL-34.
Alternative Names
Interleukin-34
UniProt
Q6ZMJ4
Immunogen
This antibody was generated by phage display, in which murine IL-34 was coated onto immunoplates and used as the antigen for antibody phage library sorting.
Application Notes
This non-neutralising antibody binds to IL-34. A Fab fragment derived from this antibody has been used in crystallisation analysis of the structure of the active core of IL-34 (Ma et al, 2012).
Antibody First Published
Ma et al. Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure. 2012 Apr 4;20(4):676-87 PMID:22483114
Note on publication
Describes the original generation of this antibody, and the use of FAb derived from this antibody to analyse the crystal structure of IL-34
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
