Cat. No.
MABL-2116
Application
Blocking, FC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
D9302C12
From
Recombinant Antibody
Specificity
This antibody is specific for murine IL-9.
Alternative Names
Interleukin-9; IL9; Cytokine P40; T-cell growth factor P40
UniProt
P15247
Immunogen
This antibody was raised by immunising Armenian hamsters with Baculovirus-expressed, recombinant murine IL-9.
Application Notes
In vitro, this antibody has inhibitory effects on IL-9 bioactivity, and inhibits the differentiation of Th17 cells and consequent production of IL-17 (Li et al, 2010). This antibody is also able to neutralise IL-9 in vivo (Li et al, 2010). Administration of this antibody suppresses acute experimental autoimmune encephalomyelitis (EAE), with an observed reduction in MOG-specific Th1 and Th17 cells in the periphery and the CNS (Li et al, 2010).
Antibody First Published
Renauld et al. Interleukin‐9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis J Leukoc Biol. 1995 57(3):353-60 PMID:7884304
Note on publication
Describes the original generation of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
