Cat. No.
MABL-2283
Application
RIA, Block, ELISA
Isotype
Engineer antibody
Species Reactivity
Species independent
Clone No.
mAbLTC
From
Recombinant Antibody
Specificity
The antibody binds to LTC4 with an EC50 of 0.11 μM.
Alternative Names
Leukotriene C4
UniProt
Immunogen
Human LTC4.
Application Notes
The antibody binds specifically to LTC4, a member of eicosanoid inflammatory mediators synthesised from arachidonic acid by arachidonate 5-lipoxygenase. LTC4 is a cysteynyl- leukotriene, and acts at the cell-surface receptors CysLT1 and CysLT2, which are both G-protein coupled receptors (GPCRs) involved in human bronchial asthma. LTC4 is responsible for increasing airway responsiveness to histamine in asthmatic patients, and antibodies that block this activity can be used in the treatment of inflammatory diseases such as asthma, and to inhibit platelet aggregation.
Antibody First Published
Matsumoto S1, Hayashi Y, Kinoshita I, Ikata T, Yamamoto S.. Immunoaffinity purification of prostaglandin E2 and leukotriene C4 prior to radioimmunoassay: application to human synovial fluid. Ann Clin Biochem. 1993 Jan;30 ( Pt 1):60-8. PMID:20079714
Note on publication
Describes the synthesis of a monoclonal antibody specific for LTC4 and its use in immunoassays to detect the amount of LTC4 in synovial fluid from patients with rheumatoid arthritis, osteoarthritis and other joint diseases.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
