Cat. No.
MABL-2349
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
MOR06626
From
Recombinant Antibody
Specificity
This antibody binds the human and murine mesothelin. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. Because of its limited expression in normal tissues and overexpression in tumors, mesothelin is a promising candidate for tumor-specific therapy.
Alternative Names
MSLN; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
UniProt
Q13421
Immunogen
The original antibody was isolated from a synthetic phage display library (HuCAL®) after 3 rounds of panning against whole CHO-A9 and NCI-H226 cells expressing mesothelin.
Application Notes
The binding reactivity of the Fab version of this antibody towards human and murine mesothelin was done using ELISA. The Fab version of this antibody binds human and murine meosthelin with a binding affinity of Kd= 6.7 × 10−10 and Kd= 6.7 × 10−9 (US9023351). The IgG1 version of this antibody was used to detect mesothelin on NCI-H226 cells by flow cytometry (US9023351).
Antibody First Published
Kahnert et al. Anti-mesothelin antibodies and uses thereof (US9023351).
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
