Cat. No.
MABL-2487
Application
activation, FC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
29A1.4
From
Recombinant Antibody
Specificity
This antibody is specific for mouse NKp46-Fc.
Alternative Names
CD335; NK-p46; NKp46; mNKp46; mAR-1; Activating receptor 1; Lymphocyte antigen 94; Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1
UniProt
Q8C567
Immunogen
The original antibody was generated by immunizing rats with mouse NKp46-Fc recombinant protein.
Application Notes
The original format of this antibody was used in an FC analysis to detect NKp46 expression on NK cells and to activate NK in an NK cell stimulation assay (Walzer et al., 2007; PMID: 17360655). This antibody was used as a component of bispecific NKCEs (Natural Killer Cell Engagers) to redirect the cytotoxic activity of NK cells towards human CD20-expressing tumor cells in a transplantable xenogeneic in vivo solid tumor model (Gauthier et al., 2019; PMID: 31155232).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
