Cat. No.
MABL-2569
Application
IP, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MRK16
From
Recombinant Antibody
Specificity
Recognizes a discontinuous extracellular epitope on P-glycoprotein.
Alternative Names
ABCB1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; CD243; MDR1; PGP; PGY1
UniProt
P08183
Immunogen
Drug resistant K-562 cells.
Application Notes
Antibody First Published
Hamada H, Tsuruo T. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7785-9. PMID:2429319
Note on publication
Describes the generation of the antibody and its ability to modulate drug cytotoxicity in vitro.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
