Cat. No.
MABL-2778
Application
Blocking, ELISA
Isotype
Engineer antibody
Species Reactivity
Plasmodium vivax
Clone No.
2A8
From
Recombinant Antibody
Specificity
The antibody binds to the 2B loop of Pvs25 with nanomolar affinity.
Alternative Names
Ookinete Pvs25; Ookinete Surface Protein Pvs-25
UniProt
D9D8M0
Immunogen
Recombinant P.vivax Pvs25.
Application Notes
This antibody binds to Pvs25, a Plasmodium surface protein constiting of a triangular arrangement of four epidermal growth-factor-like domainst tether on the cell by a glycosylphosphatidylinositol anchor. The antibody blocks the transmission of P. vivax to mosquitoes from the blood of a P. vivax-infected chimpanzee and from the blood of patients with vivax malaria.
Antibody First Published
Saxena et al. Preparation, crystallization and preliminary X-ray analysis of a complex between the Plasmodium vivax sexual stage 25 kDa protein Pvs25 and a malaria transmission- blocking antibody Fab fragment Acta Crystallography Section D Biological Crystallography 2004; 60(Pt 11):2054-2057 PMID:15502325
Note on publication
Describes the generation of a murine monoclonal antibody against recombinant Pvs25 to prevent formaiton of P. vivax oocysts in mosquitoes.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
