Cat. No.
MABL-2985
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Streptococcus pneumoniae
Clone No.
Hyp6BM8
From
Recombinant Antibody
Specificity
This S. pneumoniae serogroup 6-specific antibody binds to serogroup 6B capsular polysaccharide with an affinity of 2.44 x 10^11 M^-1.This antibody also cross-reacts with the 6A polysaccharide, with an affinity of 6.41 x 10^10 M^-1, and also reacts with serotypes 6C and 6D.
Alternative Names
CPS 6B; capsular PS 6B
UniProt
Immunogen
This antibody was raised by immunising BALB/c mice with S. pneumoniae 6B capsular polysaccharide conjugated to keyhole limpet hemocyanin.
Application Notes
This antibody has been used in flow cytometric analysis as part of a panel of serogroup 6-specific mAbs to define the serologic properties of new S. pneumoniae isolates (Oliver et al, 2013). The ability of this antibody to bind S. pneumoniae 6B and 6A serotypes has been characterised in ELISA analysis (Sun et al, 2001).
Antibody First Published
Sun et al. Avidity, Potency, and Cross-Reactivity of Monoclonal Antibodies to Pneumococcal Capsular Polysaccharide Serotype 6B Infect Immun. 2001 Jan;69(1):336-44. PMID:11119522
Note on publication
Describes the original generation of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
