Cat. No.
MABL-3200
Application
SPR
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
B1A1
From
Recombinant Antibody
Specificity
The antibody is specific for VEGFR2.
Alternative Names
flk-1;FLK-1; KDR; Fetal liver kinase 1; Kinase insert domain receptor; Protein-tyrosine kinase receptor; EC:2.7.10.1; Vascular endothelial growth factor receptor 2; Vascular endothelial growth factor receptor
UniProt
P35968
Immunogen
The original antibody was isolated by panning a phage display library against VEGFR2.
Application Notes
The bispecific antibody (A1-A8)-LALA associated with either VEGFR2 or PDLl fast and stayed on either VEGFR2 or PDLl long (KD values of BsAb (A1-A8) were about 200 pM and 3.2 pM for the hVEGFR2 and hPDLl). A cytokine secretion assay was carried out with the bispecific antibody and B1A1. The results indicate that in the present of BsAb (A1-A8)-LALA, the secretion of cytokine IL2 and INFy in PBMC when stimulated by SEB was higher than the control antibody B1A1, demonstrating that BsAb (A1-A8)-LALA retains the potency of its parental antibody B1A1 (against VEGFR2) and dsD7A8-LALA (against PDL1) (EP3411068A4).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
