Key features and details | |
Cat. No. | MABL-1368 |
Name | Anti-Der p 2.0103 mAbs |
Clone No. | AFD- 7A1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallography, inhibition, ELISA |
Species Reactivity | Dermatophagoides pteronyssinus (European house dust mite) |
Basic Information | |
Specificity | This antibody binds to an epitope on the Der p 2 which overlaps with the human IgE binding sites. The antibody recognized the six variants: Der p 2.0101, Der p 2.0102, Der p 2.0103, Der f 2.0101, Der f 2.0102, and Der f 2.0103. |
Alternative Name | DERP2; Mite group 2 allergen Der p 2; Allergen Der p II; House dust mite; DPX; Der p 2 |
UniProt | P49278 |
Immunogen | The original antibody was isolated from a combinatorial phage display library generated from a mite allergic patient. |
Application Notes | The crystal structure of Der p 2.0103–7A1Fab was determined. The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody was able to inhibit Der p 2.0103 (Glesner et al., 2019; PMID: 31554696). |
Antibody First Published | Ovsyannikova et al. Monoclonal antibodies to group II Dermatophagoides spp. Allergens: murine immune response, epitope analysis, and development of a two-site ELISA J Allergy Clin Immunol. 1994 Sep;94(3 Pt 1): 537-46. PMID: 7521892 |
Note on publication | The original paper describes the generation of the original antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
