Key features and details | |
Cat. No. | MABL-1432 |
Name | Anti-DR5 mAbs |
Clone No. | AFD-304 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, theraputic, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific to human DR5. |
Alternative Name | TRAILR2; TNFRSF10B; TRAIL receptor 2; tumor necrosis factor receptor superfamily member 10B |
UniProt | O14763 |
Immunogen | The antibody was raised in mice homozygous for both disrupted endogenous Ig heavy chain and k light chain, harboring a chromosome 14 fragment (SC20) containing a human Ig heavy chain locus and a human Igk chain transgene (KCo5). The mice were immunised against TRAIL-R1 and TRAIL-R2. |
Application Notes | This antibody has shown high anti-tumour activity in mice with subcutaneously transplanted colon carcinoma cells Colo205. It has tumour-specific cell-death-inducing activity alone in tissue culture so is expected to show anti-tumour activity independent of physiological conditions of the patient. The antibody has been shown to function in ELISA and RIA. |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
