Cat. No.
MABL-145
Application
ICC, WB
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
N419/40
From
Recombinant Antibody
Specificity
This antibody binds to most Nav1 channels. Nav1 channels mediate the voltage-dependent sodium ion permeability of excitable membranes.
Alternative Names
N419/40R; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; SCN1A
UniProt
P35498
Immunogen
This antibody was raised by immunising BALB/c mice with a synthetic peptide amino acids 1501-1518 (TEEQKKYYNAMKKLGSKK, cytoplasmic loop between repeat III and IV) of human Nav1.1.
Application Notes
This antibody was used for western blotting on adult rat brains (Gong et al, 2016; PMID:26644354). Immunocytochemistry on rat neurons was preformed with this antibody (Hefting et al, 2020; PMID:32116557) (Solé et al, 2019; PMID:30914445).
Antibody First Published
Gong et al Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities N Biotechnol. 2016 Sep 25;33(5 Pt A):551-64. PMID:26644354
Note on publication
Describes the need for good antibodies usable is neurological research and the creation of these antibodies
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
